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Compute Beyond Nature

Compute
Built with reverence. Informed by nature. De novo by intention.
Beyond

Vilya pioneers computational drug design to create de novo macrocycles — entirely new molecules inspired by biology but designed from first principles through AI-driven methods.

Inspired by nature. Designed by Vilya.

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Born from Nobel Prize-winning research at the Institute for Protein Design, we're creating medicines evolution never imagined. Our computational platform doesn't mimic biology — it extends beyond it, designing therapeutic molecules with atomic precision.

Our story
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AI-Driven macrocycle design

Our platform generates, predicts and validates entirely new macrocycles in silico. These macrocycles combine the selectivity of biologics with the convenience of pills — opening doors to previously untreatable diseases.

Our pipeline

We are advancing orally bioavailable macrocycles that could replace today's injectable biologics. Each molecule is computationally designed to hit its target with precision while crossing biological barriers that stop traditional drugs.

Internal: Oral / Permeable Drugs

Oncology Target A

50% complete

Oncology Target B

50% complete

integrin α4β7 for IBD

83.33% complete

Immunology Target C

33.33% complete

Immunology Target D

33.33% complete

Vilya in the news

From our founder's Nobel Prize to breakthrough publications in science, we're pushing the boundaries of what's possible in drug design.

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David Baker
News
(01)

Our scientific founder, Dr. David Baker, has been awarded the 2024 Nobel Prize in Chemistry for his pioneering work in computational protein design. The science behind Vilya’s mission builds directly upon Dr. Baker’s original discovery by applying advanced computational approaches to design novel, chemically diverse macrocycles to target disease biology with unprecedented precision.

Macrocycle rendering
Publication
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Vilya Announces New Publication in Science Validating Foundational Approach to Design of Novel Chemically Diverse Macrocycles

Cyrus Harmon CEO of Vilya
News
(03)

Vilya Appoints Cyrus Harmon, Ph.D., as Chief Executive Officer

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Publication
(04)

bioRxiv: Cyclic peptide structure prediction and design using AlphaFold

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News
(05)

IPD spinout Vilya computing new paths to oral macrocycle therapies

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News
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Fierce Biotech: Arch builds bridge to new class of medicines, leading $50M investment in the AI-enabled Vilya

Join our mission

We're assembling a team of computational biologists, chemists, and builders who believe the best medicines haven't been discovered — they need to be designed.

Open positions
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Let’s build the future of therapeutics

Whether you're exploring partnership, investment, or collaboration — we'd love to hear from you.

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